GW0742 = 98 HPLC 317318-84-6 - Sigma-Aldrich

gw0742  GW0742 is a potent and highly selective PPARβδ agonist, with IC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ  Administration of GW0742 30 min before and 30 min after a challenge with CAR caused a reduction in all the parameters of inflammation

As a PPAR delta agonist, GW0742 enhances fatty acid metabolism This in turn preserves blood sugar as well as physical endurance It is because of this effect GW0742 is a synthetic, potent and selective PPAR-βδ agonist PPARs are ligand-dependent transcription factors which are involved in many physiological

Conclusion GW0742 reduces the cellular and molecular changes occurring in SCI by targeting different downstream pathways modulating PPAR-δ receptors Three GW0742 is a synthetic, potent and selective PPAR-βδ agonist PPARs are ligand-dependent transcription factors which are involved in many physiological